The glucose-fatty acid cycle. Relationship between glucose utilization in muscle, fatty acid oxidation in muscle and lipolysis in adipose tissue.

  title={The glucose-fatty acid cycle. Relationship between glucose utilization in muscle, fatty acid oxidation in muscle and lipolysis in adipose tissue.},
  author={J. C. Stanley},
  journal={British journal of anaesthesia},
  volume={53 2},
  • J. C. Stanley
  • Published 1981
  • Medicine
  • British journal of anaesthesia
This series of articles is concerned with how carbohydrate, lipid and amino acid metabolism in different tissues is integrated for the benefit of the whole animal. The tissues of the body oxidize a variety of organic compounds for production of biological energy in the form of ATP. These compounds include glucose, fatty acids, ketone bodies and some amino acids and for the purpose of these articles they can be grouped together under the term metabolic fuels. They are obtained either from the… Expand
731 Citations
Regulation of nutrient metabolism and energy expenditure.
In obesity, glucose intolerance and insulin resistance can be prevented, or if already existing, can be decreased by stimulating glycogen mobilization by exercise, thermogenesis-stimulating drugs, and weight loss, which reduces fat stores and decreases lipid oxidation. Expand
In vivo regulation of lipolysis in humans.
Considerable additional research is needed in order to fully understand both normal lipolytic regulation and the abnormalities of lipolysis which accompany pathological conditions. Expand
Post-Genomic Analysis of Fatty Acid and Glucose Metabolism in Cardiovascular Disease
Current understanding of the mechanisms and treatment of metabolic dysfunctions observed in animal models and occurring in human cardiac disorders are discussed. Expand
Role of fatty acid uptake and fatty acid beta-oxidation in mediating insulin resistance in heart and skeletal muscle.
The proposed mechanisms by which alterations in fatty acid uptake and oxidation contribute to insulin resistance are discussed, and how targeting fatty acid usage and oxidation is a potential therapeutic approach to treat insulin resistance is discussed. Expand
Principles of Fuel Metabolism in Heart Muscle
This chapter reviews the mechanisms of metabolic control and fuel selection, as they relate to the function of the heart, with particular emphasis on the interaction between substrates and the control of the citric acid cycle, the final common pathway for all substrates providing reducing equivalents for the respiratory chain. Expand
New Insights into the Interaction of Carbohydrate and Fat Metabolism During Exercise
  • L. Spriet
  • Chemistry, Medicine
  • Sports Medicine
  • 2014
Information has led to the proposal of mechanisms to explain the downregulation of fat metabolism that occurs in the face of increasing carbohydrate availability and when moving from moderate to intense aerobic exercise. Expand
Myocardial fatty acid metabolism in health and disease.
The regulation of myocardial fatty acid beta-oxidation is reviewed and how alterations in fatty acid Beta-Oxidation can contribute to heart disease is discussed. Expand
Regulation of the plasma non-esterified fatty acid concentration in the postprandial state.
There is evidence from studies with isolated hepatocytes that NEFA may reduce hepatocyte insulin binding, thus reducing the normal large extraction of insulin which occurs on its first passage through the liver, and therefore, inappropriately elevated NEFA concentrations may be seen as central to the insulin resistance syndrome. Expand
Role of substrate competition in the pathogenesis of insulin resistance in man.
Increased availability of lipid and amino acid substrates may possibly exert important effects on glucose metabolism which could contribute to insulin resistance. Expand
Fatty acids and insulin resistance in muscle and liver.
  • P. Kovacs, M. Stumvoll
  • Biology, Medicine
  • Best practice & research. Clinical endocrinology & metabolism
  • 2005
The main aspects of FFA metabolism in the development of insulin resistance in skeletal muscle and liver, as well as the role of ectopic lipid deposits as a local source of FFAs are reviewed. Expand


Regulation of Glucose Uptake by Muscle
The uptake of glucose by muscle is a complex process, which is thought to involve, in sequence, passage of the sugar from capillaries to the muscle cell membrane, transfer across the cell membranes, and metabolism within the cell by multienzyme systems with their various cofactors. Expand
Citrate as an Intermediary in the Inhibition of Phosphofructokinase in Rat Heart Muscle by Fatty Acids, Ketone Bodies, Pyruvate, Diabetes and Starvation
Observations suggest that anoxia and uncouplers of respiratory chain phosphorylation increase the rate of the phosphofructokinase reaction in muscle (and hence of glycolysis) by increasing the concentrations of 5′ AMP, ADP and inorganic phosphate and diminishing that of ATP. Expand
Hormonal control of adipose-tissue lipolysis.
It appears that enhanced rates of lipolysis in vivo, for example during fasting and exercise, may be a substantial fraction of the maximum obtainable by hormone stimulation in vitro. Expand
Fatty Acid and Glucose Metabolism in the Perfused Heart
PREVIOUS work on intact animals in which arteriovenous differences across the myocardium were measured1,2 have suggested that fatty acids are an important metabolite for the heart. No work has beenExpand
Inhibition of glucose uptake and glycogenolysis by availability of oleate in well-oxygenated perfused skeletal muscle.
It is concluded that, as in the heart, availability of fatty acids has an inhibitory effect on glucose uptake and glycogen utilization in well-oxygenated red skeletal muscle. Expand
Effects of ventricular pressure development and palmitate on glucose transport.
The conclusion that glucose transport was the step in glucose utilization affected by ventricular pressure development and fatty acids was substantiated by the demonstration that palmitate inhibited the accelerated rate of 3Gmethylglucose transport associated with increased pressure development. Expand
The metabolism of glucose U-C14, 5 mm, and palmitate 1-C14, 0.75 mm (complexed to 0.5% albumin), was studied in isolated perfused hearts taken from three groups of rats: fed ad libitum, fasted over...
The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects.
Elevated levels of insulin, in both the basal state and in response to glucose, were related to obesity. Expand
Pyruvate metabolism in the perfused rat heart.
The metabolism of C14-labeled pyruvate in the isolated heart was studied in a closed recirculation system. Decarboxylation was the major fate of pyruvate-1-C14 and increased according to the concen...