The glucose-fatty acid cycle. Relationship between glucose utilization in muscle, fatty acid oxidation in muscle and lipolysis in adipose tissue.

@article{Stanley1981TheGA,
  title={The glucose-fatty acid cycle. Relationship between glucose utilization in muscle, fatty acid oxidation in muscle and lipolysis in adipose tissue.},
  author={J. C. Stanley},
  journal={British journal of anaesthesia},
  year={1981},
  volume={53 2},
  pages={
          123-9
        }
}
  • J. C. Stanley
  • Published 1981
  • Medicine
  • British journal of anaesthesia
This series of articles is concerned with how carbohydrate, lipid and amino acid metabolism in different tissues is integrated for the benefit of the whole animal. The tissues of the body oxidize a variety of organic compounds for production of biological energy in the form of ATP. These compounds include glucose, fatty acids, ketone bodies and some amino acids and for the purpose of these articles they can be grouped together under the term metabolic fuels. They are obtained either from the… Expand
731 Citations
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Current understanding of the mechanisms and treatment of metabolic dysfunctions observed in animal models and occurring in human cardiac disorders are discussed. Expand
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Information has led to the proposal of mechanisms to explain the downregulation of fat metabolism that occurs in the face of increasing carbohydrate availability and when moving from moderate to intense aerobic exercise. Expand
Myocardial fatty acid metabolism in health and disease.
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The regulation of myocardial fatty acid beta-oxidation is reviewed and how alterations in fatty acid Beta-Oxidation can contribute to heart disease is discussed. Expand
Regulation of the plasma non-esterified fatty acid concentration in the postprandial state.
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There is evidence from studies with isolated hepatocytes that NEFA may reduce hepatocyte insulin binding, thus reducing the normal large extraction of insulin which occurs on its first passage through the liver, and therefore, inappropriately elevated NEFA concentrations may be seen as central to the insulin resistance syndrome. Expand
Role of substrate competition in the pathogenesis of insulin resistance in man.
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Increased availability of lipid and amino acid substrates may possibly exert important effects on glucose metabolism which could contribute to insulin resistance. Expand
Fatty acids and insulin resistance in muscle and liver.
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The main aspects of FFA metabolism in the development of insulin resistance in skeletal muscle and liver, as well as the role of ectopic lipid deposits as a local source of FFAs are reviewed. Expand
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The uptake of glucose by muscle is a complex process, which is thought to involve, in sequence, passage of the sugar from capillaries to the muscle cell membrane, transfer across the cell membranes, and metabolism within the cell by multienzyme systems with their various cofactors. Expand
Citrate as an Intermediary in the Inhibition of Phosphofructokinase in Rat Heart Muscle by Fatty Acids, Ketone Bodies, Pyruvate, Diabetes and Starvation
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