The glucocorticoid-responsive gene cascade. Activation of the rat arginase gene through induction of C/EBPbeta.

@article{Gotoh1997TheGG,
  title={The glucocorticoid-responsive gene cascade. Activation of the rat arginase gene through induction of C/EBPbeta.},
  author={Tomomi Gotoh and Shoaib Chowdhury and Masaki Takiguchi and Masataka Mori},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 6},
  pages={3694-8}
}
The gene for liver-type arginase, an ornithine cycle enzyme, is induced by glucocorticoids in a delayed secondary manner. An enhancer element located around intron 7 of the rat arginase gene shows delayed glucocorticoid responsiveness, and it harbors two sites binding with members of the CCAAT/enhancer binding protein (C/EBP) family. Here, we investigate the role of these C/EBP binding sites in glucocorticoid response of the arginase gene. When inserted in front of the herpes simplex virus… CONTINUE READING