The glucocorticoid receptor represses cyclin D1 by targeting the Tcf-beta-catenin complex.

@article{Takayama2006TheGR,
  title={The glucocorticoid receptor represses cyclin D1 by targeting the Tcf-beta-catenin complex.},
  author={Sachiko Takayama and Inez Rogatsky and Leslie E Schwarcz and Beatrice D. Darimont},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 26},
  pages={17856-63}
}
The ability of glucocorticoids (GCs) to regulate cell proliferation plays an important role in their therapeutic use. The canonical Wnt pathway, which promotes the proliferation of many cancers and differentiated tissues, is an emerging target for the actions of GCs, albeit existing links between these signaling pathways are indirect. By screening known Wnt target genes for their ability to respond differently to GCs in cells whose proliferation is either positively or negatively regulated by… CONTINUE READING

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