The glucocorticoid receptor in the distal nephron is not necessary for the development or maintenance of dexamethasone-induced hypertension.

@article{Goodwin2010TheGR,
  title={The glucocorticoid receptor in the distal nephron is not necessary for the development or maintenance of dexamethasone-induced hypertension.},
  author={Julie E. Goodwin and Junhui Zhang and Heino Vel{\'a}zquez and David S. Geller},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={394 2},
  pages={
          266-71
        }
}
Glucocorticoids are used as a treatment for a variety of conditions and hypertension is a well-recognized side effect of their use. The mechanism of glucocorticoid-induced hypertension is incompletely understood and has traditionally been attributed to promiscuous activation of the mineralocorticoid receptor by cortisol. Multiple lines of evidence, however, point to the glucocorticoid receptor as an important mediator as well. We have developed a mouse model of glucocorticoid-induced… CONTINUE READING

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