The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals

@inproceedings{Watson2013TheGR,
  title={The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals},
  author={Lawrence C. Watson and Kristopher M. Kuchenbecker and Benjamin J. Schiller and John D Gross and Miles A Pufall and Koh'ichiroh Yamamoto},
  booktitle={Nature Structural &Molecular Biology},
  year={2013}
}
Glucocorticoid receptor (GR) binds to genomic response elements and regulates gene transcription with cell and gene specificity. Within a response element, the precise sequence to which the receptor binds has been implicated in directing its structure and activity. Here, we use NMR chemical-shift difference mapping to show that nonspecific interactions with bases at particular positions in the binding sequence, such as those of the 'spacer', affect the conformation of distinct regions of the… CONTINUE READING
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