The glucagon receptor antagonist BI-32169 constitutes a new class of lasso peptides.

  title={The glucagon receptor antagonist BI-32169 constitutes a new class of lasso peptides.},
  author={Thomas A Knappe and Uwe Linne and Xiulan Xie and Mohamed A. Marahiel},
  journal={FEBS letters},
  volume={584 4},
The glucagon receptor antagonist BI-32169, recently isolated from Streptomyces sp., was described as a bicyclic peptide, although its primary structure comprises conserved elements of class I and class II lasso peptides. Tandem mass spectrometric and nuclear magnetic resonance spectroscopic studies revealed that BI-32169 is a lasso-structured peptide constituting the new class III of lasso peptides. The determined lasso fold opens new avenues to improve the promising biological activity of BI… CONTINUE READING

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