The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances beta-cell function but does not inhibit gastric emptying in mice.

@article{Maida2008TheGP,
  title={The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances beta-cell function but does not inhibit gastric emptying in mice.},
  author={Adriano Maida and Julie A Lovshin and Laurie L. Baggio and Daniel J Drucker},
  journal={Endocrinology},
  year={2008},
  volume={149 11},
  pages={5670-8}
}
The proglucagon gene gives rise to multiple peptides that play diverse roles in the control of energy intake, gut motility, and nutrient disposal. Glucagon-like peptide-1 (GLP-1), a 30-amino-acid peptide regulates glucose homeostasis via control of insulin and glucagon secretion and by inhibition of gastric emptying and food intake. Oxyntomodulin (OXM) a 37-amino-acid peptide also derived from the proglucagon gene, binds to both the glucagon and GLP-1 receptor (GLP-1R); however, a separate OXM… CONTINUE READING

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Differential effects of oxyntomodulin and GLP-1 on glucose metabolism.

American journal of physiology. Endocrinology and metabolism • 2012
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Unraveling oxyntomodulin, GLP1's enigmatic brother

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