The global histone modification pattern correlates with overall survival in metachronous liver metastasis of colorectal cancer.

@article{Tamagawa2012TheGH,
  title={The global histone modification pattern correlates with overall survival in metachronous liver metastasis of colorectal cancer.},
  author={Hiroshi Tamagawa and Takashi Oshima and Manabu Shiozawa and Soichiro Morinaga and Yoshiyasu Nakamura and Mitsuyo Yoshihara and Yuji Sakuma and Yoichi Kameda and Makoto Akaike and Munetaka Masuda and Toshio Imada and Yohei Miyagi},
  journal={Oncology reports},
  year={2012},
  volume={27 3},
  pages={637-42}
}
Post-translational histone modifications are known to be altered in cancer tissues, and differences in the histone modification levels have recently been used to predict the clinical outcome in patients with certain types of cancer. In this study, we evaluated the immunohistochemical staining patterns of histone H3 dimethylation and acetylation in metachronous liver metastasis of colorectal carcinomas and examined its correlation with… CONTINUE READING