The global burden of group A streptococcal diseases.

@article{Carapetis2005TheGB,
  title={The global burden of group A streptococcal diseases.},
  author={Jonathan R Carapetis and Andrew C. Steer and Edward Kim Mulholland and Martin Willi Weber},
  journal={The Lancet. Infectious diseases},
  year={2005},
  volume={5 11},
  pages={
          685-94
        }
}
The global burden of disease caused by group A streptococcus (GAS) is not known. We review recent population-based data to estimate the burden of GAS diseases and highlight deficiencies in the available data. We estimate that there are at least 517,000 deaths each year due to severe GAS diseases (eg, acute rheumatic fever, rheumatic heart disease, post-streptococcal glomerulonephritis, and invasive infections). The prevalence of severe GAS disease is at least 18.1 million cases, with 1.78… Expand

Paper Mentions

Observational Clinical Trial
The purpose of the research is to help understand why some children become carriers of strep and whether children who are carriers need to be treated with antibiotics.  
ConditionsStreptococcal Pharyngitis
InterventionOther
News Article
Blog Post
Observational Clinical Trial
This study will determine the prevalence of rheumatic heart disease (RHD) in Lusaka, Zambia through school-based screening methodology using ultraportable echocardiography and a… Expand
ConditionsRheumatic Heart Disease
Group a streptococcal diseases and their global burden.
TLDR
The need to support improved surveillance and epidemiological research in low-resource settings in order to enable better assessment of national and global disease burdens, target control strategies appropriately and assess the success of control interventions is highlighted. Expand
RATIONALE FOR GROUP A STREPTOCOCCAL VACCINES
RATIONALE FOR GROUP A STREPTOCOCCAL VACCINES vaccines against Streptococcus pyogenes (the Lancefield group a streptococcus [Gas]) have been a goal of researchers and public health authorities sinceExpand
[Epidemiology of Streptococcus pyogenes infections in developing countries].
TLDR
Group A streptococcal (GAS) infections are frequent in developing countries but the epidemiology is incompletely known, and clinical features of GAS invasive infections are identical to those reported in developed countries, but frequency and mortality are higher, as is the number of the different emm types involved. Expand
Streptococcal skin infection and rheumatic heart disease
TLDR
The available data support the hypothesis that group A streptococcal impetigo plays a role in the pathogenesis of RHD, and there is increasing evidence of skin-associated strains being linked to cases of rheumatic fever. Expand
Prevalence of group A streptococcal disease in North and Sub-Saharan Africa: a systematic review protocol
TLDR
A systematic review of studies measuring the prevalence of GAS infection among people in North and Sub-Saharan African countries will provide updated evidence of a review published in 2009 and have implications for the development of a GAS vaccine. Expand
Prevalence of group A Streptococcal infection in Africa to inform GAS vaccines for rheumatic heart disease: A systematic review and meta-analysis.
TLDR
The prevalence of group A streptococcal disease remains high among symptomatic individuals residing in Africa and the frequency and distribution of emm types among isolates and the need for further studies is warranted to inform current prevention efforts including vaccine development. Expand
Clonal Diversity of Group A Streptococci Causing Human Infections in Southern India.
TLDR
This is the first study in India utilizing the technique multi locus sequence typing (MLST) for GAS which increased the information on diversity of GAS infections and identified the clonal complexes present in the GAS isolates from the community and the hospital isolates. Expand
Group A streptococcus epidemiology and vaccine implications.
  • R. Cohen-Poradosu, D. Kasper
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2007
TLDR
These figures place GAS among the world's major human pathogens, exceeded only by HIV, Mycobacterium tuberculosis, Plasmodium falciparum, and Streptococcus pneumoniae, with mortality rates comparable to those for rotavirus infection, measles, Haemophilus influenzae type b infection, and hepatitis. Expand
Rationale and design of the African group A streptococcal infection registry: the AFROStrep study
TLDR
The AFROStrep study seeks to collect comprehensive data on GAS isolates in Africa and will serve as a platform for vaccine development in Africa through peer-reviewed journal articles, conference publications and proceedings. Expand
Disease Manifestations and Pathogenic Mechanisms of Group A Streptococcus
TLDR
Genomic and molecular analyses have now characterized a large number of GAS virulence determinants, many of which exhibit overlap and redundancy in the processes of adhesion and colonization, innate immune resistance, and the capacity to facilitate tissue barrier degradation and spread within the human host. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 53 REFERENCES
Invasive group A streptococcal disease in metropolitan Atlanta: a population-based assessment.
  • C. Zurawski, M. Bardsley, +4 authors M. Farley
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1998
TLDR
Active, population-based surveillance for invasive group A streptococcal (GAS) disease was conducted in laboratories in metropolitan Atlanta from 1 January 1994 through 30 June 1995 to further define risk factors and risk of secondary cases and to develop effective prevention strategies. Expand
Invasive group A streptococcal infections in Ontario, Canada. Ontario Group A Streptococcal Study Group.
TLDR
The elderly and those with underlying medical conditions are at greatest risk for invasive group A streptococcal disease, toxic shock, and necrotizing fasciitis. Expand
The changing epidemiology of invasive group A streptococcal infections and the emergence of streptococcal toxic shock-like syndrome. A retrospective population-based study.
TLDR
Significant changes occurred in the spectrum of invasive group A streptococcal infections in Pima County, Arizona, between 1985 and 1990, and Native Americans were at increased risk of acquiring these infections. Expand
Clinical and epidemiological features of group A streptococcal bacteraemia in a region with hyperendemic superficial streptococcal infection.
TLDR
Genetic typing of isolates revealed no dominant strains and no evidence of a clone which has been a common cause of these infections elsewhere, and there was no significant difference in the proportion of Aboriginal compared to non-Aboriginal patients with at least one risk factor. Expand
Epidemiological and clinical aspects of invasive group A streptococcal infections and the streptococcal toxic shock syndrome.
TLDR
A review of 151 invasive episodes occurring in 1983-1995 showed cyclic increases of infections due to T1M1-serotype strains during 1986-1990 and 1993-1995 and Hypotension was significantly associated with a fatal outcome, regardless of whether STSS developed. Expand
The burden of group A streptococcal pharyngitis in Melbourne families.
TLDR
The present data suggest that GAS pharyngitis remains very common in childhood, and that it has further implications in terms of secondary cases and costs. Expand
Cumulative incidence of rheumatic fever in an endemic region: a guide to the susceptibility of the population?
TLDR
Comparisons suggest that the major part of the variation in rheumatic fever incidence between populations is due to differences in streptococcal exposure and treatment, rather than to any difference in (genetic) susceptibility. Expand
The natural history of rheumatic fever and rheumatic heart disease in the Orient.
TLDR
It is concluded that there is no uniform "Oriental-type" of natural history of RF and RHD, and the natural history varies greatly among countries as is true in other parts of the world. Expand
Invasive group A streptococcal disease in North Queensland (1996 - 2001).
TLDR
Invasive group A streptococci from North Queensland are similar to those from the Northern Territory of Australia in that no single strain is predominant and the indigenous population is overrepresented. Expand
Group A streptococcal strains in Kuwait: a nine‐year prospective study of prevalence and associations
TLDR
The findings support the concept of nephritogenicity of some streptococcal strains among the prevalent strains and show the value of long term studies in detecting the changes in the prevalence of streptitiscal strains in the community. Expand
...
1
2
3
4
5
...