The glio-toxic mechanism of alpha-aminoadipic acid on cultured astrocytes.

@article{Brown1998TheGM,
  title={The glio-toxic mechanism of alpha-aminoadipic acid on cultured astrocytes.},
  author={David R Brown and Hans A. Kretzschmar},
  journal={Journal of neurocytology},
  year={1998},
  volume={27 2},
  pages={
          109-18
        }
}
The mechanism of action of the glutamate analogue alpha-aminoadipic (AAA) acid was investigated in terms of its toxicity to cultured astrocytes. AAA was more toxic to type 1 astrocytes than type 2 astrocytes. Also the higher toxicity of the L-isomer as compared to the D-isomer was seen on type 1 astrocytes but not type 2. The toxicity of AAA can be reduced by co-culture of type 1 astrocytes with microglia. This inhibition may be due to glutamate release by microglia. No such effect is seen for… CONTINUE READING

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