The glial response to injury and its role in the inhibition of CNS repair.

@article{Fawcett2006TheGR,
  title={The glial response to injury and its role in the inhibition of CNS repair.},
  author={James W. Fawcett},
  journal={Advances in experimental medicine and biology},
  year={2006},
  volume={557},
  pages={
          11-24
        }
}
The failure of axon regeneration after CNS injury is due to an inadequate or inappropriate regenerative response from damaged CNS axons and to a CNS environment that inhibits regeneration. This inhibitory environment contains many molecules that promote axon growth as well as molecules that inhibit it, but the balance of activities in the damaged CNS does not favour the regeneration of adult CNS axons. In principle, therefore, axon regeneration could be achieved in three ways: (1) Inhibitory… CONTINUE READING
Highly Cited
This paper has 25 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-9 of 9 citations

References

Publications referenced by this paper.
Showing 1-10 of 69 references

Chondroitinase ABC promotes axon regeneration and functional recovery following spinal cord injury

  • EJ Bradbury, Moon LDF, RJ Popat
  • Nature
  • 2002