The germinal center reaction.

  title={The germinal center reaction.},
  author={Dominique Gatto and Robert Brink},
  journal={The Journal of allergy and clinical immunology},
  volume={126 5},
  pages={898-907; quiz 908-9}
The germinal center (GC) reaction is the basis of T-dependent humoral immunity against foreign pathogens and the ultimate expression of the adaptive immune response. GCs represent a unique collaboration between proliferating antigen-specific B cells, T follicular helper cells, and the specialized follicular dendritic cells that constitutively occupy the central follicular zones of secondary lymphoid organs. The primary function of GCs is to produce the high-affinity antibody-secreting plasma… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 54 extracted citations

Connexins and pannexins in the immune system and lymphatic organs

Cellular and Molecular Life Sciences • 2015
View 11 Excerpts
Highly Influenced

Chronic Lymphocytic Leukemia

Molecular and Translational Medicine • 2018

Novel function of hydroxychloroquine: Down regulation of T follicular helper cells in collagen-induced arthritis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie • 2018
View 1 Excerpt

Similar Papers

Loading similar papers…