The germinal center reaction.

@article{Gatto2010TheGC,
  title={The germinal center reaction.},
  author={Dominique Gatto and Robert Brink},
  journal={The Journal of allergy and clinical immunology},
  year={2010},
  volume={126 5},
  pages={898-907; quiz 908-9}
}
The germinal center (GC) reaction is the basis of T-dependent humoral immunity against foreign pathogens and the ultimate expression of the adaptive immune response. GCs represent a unique collaboration between proliferating antigen-specific B cells, T follicular helper cells, and the specialized follicular dendritic cells that constitutively occupy the central follicular zones of secondary lymphoid organs. The primary function of GCs is to produce the high-affinity antibody-secreting plasma… CONTINUE READING

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