The genotoxicity of enantiomeric aliphatic epoxides.

  title={The genotoxicity of enantiomeric aliphatic epoxides.},
  author={J. E. Sinsheimer and R. Chen and S. K. Das and B. H. Hooberman and S. Osorio and Z. You},
  journal={Mutation research},
  volume={298 3},
  • J. E. Sinsheimer, R. Chen, +3 authors Z. You
  • Published 1993
  • Chemistry, Medicine
  • Mutation research
  • The (R)- and (S)-optical isomers of 9 epoxides, benzyloxymethyloxirane, epichlorohydrin, glycidol, glycidyl 3-nitrobenzenesulfonate, glycidyl 4-nitrobenzoate, glycidyl tosylate, styrene oxide, glycidyl 1-naphthyl ether and glycidyl 4-nitrophenyl ether, have been compared for their in vivo and in vitro genotoxicity. The in vitro short-term test employed was the Ames mutagenicity assay with Salmonella strain TA100. The in vivo tests were chromosomal aberrations (CA) as well as sister-chromatid… CONTINUE READING
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