The genomic signature of dog domestication reveals adaptation to a starch-rich diet

@article{Axelsson2013TheGS,
  title={The genomic signature of dog domestication reveals adaptation to a starch-rich diet},
  author={E. Axelsson and A. Ratnakumar and M. Arendt and K. Maqbool and M. Webster and M. Perloski and O. Liberg and J. Arnemo and {\AA}. Hedhammar and K. Lindblad-Toh},
  journal={Nature},
  year={2013},
  volume={495},
  pages={360-364}
}
The domestication of dogs was an important episode in the development of human civilization. The precise timing and location of this event is debated and little is known about the genetic changes that accompanied the transformation of ancient wolves into domestic dogs. Here we conduct whole-genome resequencing of dogs and wolves to identify 3.8 million genetic variants used to identify 36 genomic regions that probably represent targets for selection during dog domestication. Nineteen of these… Expand
Identification of genomic variants putatively targeted by selection during dog domestication
TLDR
The first genome-wide analysis of the different categories of putatively functional variants that are fixed or segregating at high frequency between a global sampling of dogs and wolves finds evidence that selection has been strongest around non-synonymous variants. Expand
Selective sweep analysis using village dogs highlights the pivotal role of the neural crest in dog domestication
TLDR
It is proposed that initial selection acted on key genes in the neural crest and minor splicing pathways during early dog domestication, giving rise to the phenotypes of modern dogs. Expand
Evolutionary genomics: Detecting selection
TLDR
Results suggest that dogs may have found a new ecological niche, scavenging waste from human settlements established during the agricultural revolution, and modern dogs fare better than carnivorous wolves on a diet rich in starch. Expand
Comparison of village dog and wolf genomes highlights the role of the neural crest in dog domestication
TLDR
Signals persisting in dog genomes are used to identify genes that act early in embryogenesis and can confer phenotypes distinguishing domesticated dogs from wolves, such as tameness, smaller jaws, floppy ears, and diminished craniofacial development as the targets of selection during domestication. Expand
Amy2B copy number variation reveals starch diet adaptations in ancient European dogs
TLDR
It is suggested that selection for the increased Amy2B copy number started 7000 years cal. Expand
Comparison of village dog and wolf genomes highlights the pivotal role of the neural crest in dog domestication
TLDR
Signs persisting in the dog genome are used to identify genes and pathways altered by the intensive selective pressures of domestication and indicate that phenotypes distinguishing domesticated dogs from wolves, such as tameness, smaller jaws, floppy ears, and diminished craniofacial development, are determined by genes which act early in embryogenesis. Expand
Convergent genomic signatures of domestication in sheep and goats
TLDR
Comparing the genomes of wild Asiatic mouflon and Bezoar ibex with that of domestics from local, traditional and improved breeds finds common targets of selection related to domestication and improvement in sheep and goats. Expand
Genomic analysis of dingoes identifies genomic regions under reversible selection during domestication and feralization
TLDR
The results indicate that adaptation to domestication and feralization primarily affected different genomic regions, but that some genes, related to neurodevelopment, metabolism and reproduction, may have been reversibly affected in the two processes. Expand
Whole genome resequencing of the Iranian native dogs and wolves to unravel variome during dog domestication
TLDR
The results showed more deleterious mutations and coding sequence variants in the domestic dog genome than those in wolf genome, which contribute to understanding the genetic architecture of the dog domestication. Expand
Genomic regions under selection in the feralization of the dingoes
TLDR
The results indicate that the feralization of the dingo induced positive selection on genomic regions correlated to neurodevelopment, metabolism and reproduction, in adaptation to a wild environment. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 44 REFERENCES
Whole-genome resequencing reveals loci under selection during chicken domestication
TLDR
The use of massively parallel sequencing is described to identify selective sweeps of favourable alleles and candidate mutations that have had a prominent role in the domestication of chickens and their subsequent specialization into broiler (meat- producing) and layer (egg-producing) chickens. Expand
Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication
TLDR
It is shown that dog breeds share a higher proportion of multi-locus haplotypes unique to grey wolves from the Middle East, indicating that they are a dominant source of genetic diversity for dogs rather than wolves from east Asia, as suggested by mitochondrial DNA sequence data. Expand
Genome sequence, comparative analysis and haplotype structure of the domestic dog
TLDR
A high-quality draft genome sequence of the domestic dog is reported, together with a dense map of single nucleotide polymorphisms (SNPs) across breeds, to shed light on the structure and evolution of genomes and genes. Expand
Contrasting Mode of Evolution at a Coat Color Locus in Wild and Domestic Pigs
TLDR
Investigation of sequence diversity at the porcine melanocortin receptor 1 (MC1R) locus provides evidence that wild and domestic pig (Sus scrofa) haplotypes from China and Europe are the result of strikingly different selection pressures, and that coat color variation is the results of intentional selection for alleles that appeared after the advent of domestication. Expand
Diet and the evolution of human amylase gene copy number variation
TLDR
It is found that copy number of the salivary amylase gene (AMY1) is correlated positively with salivaries protein level and that individuals from populations with high-starch diets have, on average, more AMY1 copies than those with traditionally low-st starch diets. Expand
Studying phenotypic evolution in domestic animals: a walk in the footsteps of Charles Darwin.
  • L. Andersson
  • Biology, Medicine
  • Cold Spring Harbor symposia on quantitative biology
  • 2009
TLDR
A major discovery made using this pedigree is the identification of a single-nucleotide substitution in intron 3 of the gene for insulin-like growth factor 2 (IGF2) that is underlying a quantitative trait locus affecting muscle growth, size of the heart, and fat deposition. Expand
Destabilizing selection as a factor in domestication
TLDR
The hypothesis that the loss of the strict seasonal rhythm of reproduction and of the monoestrous condition inherent in wild animals was a conseThis paper is based on the lecture presented on August 30, 1978, as the Fifteenth Wilhelmine E. Key lecture at the XIV International Congress of Genetics in Moscow. Expand
mtDNA Data Indicate a Single Origin for Dogs South of Yangtze River, Less Than 16,300 Years Ago, from Numerous Wolves
TLDR
Results indicate that the domestic dog originated in southern China less than 16,300 ya, from several hundred wolves, suggesting that the dogs may have originated among sedentary hunter-gatherers or early farmers, and the numerous founders indicate that wolf taming was an important culture trait. Expand
The remarkable evolutionary history of the human amylase genes.
  • M. Meisler, C. Ting
  • Biology, Medicine
  • Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists
  • 1993
Analysis of the structures of the human amylase genes has demonstrated that this multigene family contains at least five tandem gene copies, closely related in sequence but with distinct tissueExpand
Estimation of population divergence times from non-overlapping genomic sequences: examples from dogs and wolves.
TLDR
An approach to estimate population divergence times for non-overlapping sequence data that is based on probabilities of different genealogical topologies under a structured coalescent model is described and can be adapted to accommodate common problems such as sequencing errors and postmortem nucleotide misincorporations. Expand
...
1
2
3
4
5
...