The genomic response of the Drosophila embryo to JNK signaling.

  title={The genomic response of the Drosophila embryo to JNK signaling.},
  author={Heinrich Jasper and Vladimir Benes and Christian Schwager and Silvia Sauer and Sandra Clauder-Muenster and Wilhelm Ansorge and Dirk Bohmann},
  journal={Developmental cell},
  volume={1 4},
During Drosophila development, the Jun N-terminal kinase signal transduction pathway regulates morphogenetic tissue closure movements that involve cell shape changes and reorganization of the actin cytoskeleton. We analyzed the genome-wide transcriptional response to activation of the JNK pathway in the Drosophila embryo by serial analysis of gene expression (SAGE) and identified loci encoding cell adhesion molecules and cytoskeletal regulators as JNK responsive genes. The role of one of the… CONTINUE READING


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