The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids

@article{Hamer2008TheGP,
  title={The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids},
  author={Philip C. de Witt Hamer and Angela A. G. van Tilborg and Paul P. Eijk and Peter Sminia and Dirk Troost and Cornelis J. F. van Noorden and Bauke Ylstra and S. Leenstra},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={2091-2096}
}
Screening of therapeutics relies on representative cancer models. The representation of human glioblastoma by in vitro cell culture models is questionable. We obtained genomic profiles by array comparative genomic hybridization of both short- and long-term primary cell and spheroid cultures, derived from seven glioblastomas and one anaplastic oligodendroglioma. Chromosomal copy numbers were compared between cell cultures and spheroids and related to the parental gliomas using unsupervised… CONTINUE READING
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