The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast.

  title={The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast.},
  author={Wenfeng Qian and Di Ma and Che Xiao and Zhi Wang and Jianzhi Zhang},
  journal={Cell reports},
  volume={2 5},
Antagonistic pleiotropy (AP), or genetic tradeoff, is an important concept that is frequently invoked in theories of aging, cancer, genetic disease, and other common phenomena. However, the prevalence of AP, which genes are subject to AP, and to what extent and how AP may be resolved remain unclear. By measuring the fitness difference between the wild-type and null alleles of ~5,000 nonessential genes in yeast, we found that in any given environment, yeast expresses hundreds of genes that harm… CONTINUE READING
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Impact of gene expression noise on organismal fitness and the efficacy of natural selection

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