The genomic determinants of alcohol preference in mice

  title={The genomic determinants of alcohol preference in mice},
  author={Boris Tabakoff and Laura M. Saba and Katherina J Kechris and Wei Hu and S. V. Bhave and Deborah Ann Finn and Nicholas J Grahame and Paula L. Hoffman},
  journal={Mammalian Genome},
Searches for the identity of genes that influence the levels of alcohol consumption by humans and other animals have often been driven by presupposition of the importance of particular gene products in determining positively or negatively reinforcing effects of ethanol. We have taken an unbiased approach and performed a meta-analysis across three types of mouse populations to correlate brain gene expression with levels of alcohol intake. Our studies, using filtering procedures based on QTL… CONTINUE READING