The genomic breakpoint in a patient with Philadelphia-positive acute leukemia is 5' of the breakpoint cluster region.

@article{Rassool1988TheGB,
  title={The genomic breakpoint in a patient with Philadelphia-positive acute leukemia is 5' of the breakpoint cluster region.},
  author={F Rassool and Letizia Foroni and Amin Rahemtulla and O. Dreazen and Leanne M Wiedemann and Alex Guo and Steve Legon and Daniel Catovsky and Lucio Luzzatto and J M Goldman},
  journal={Cancer genetics and cytogenetics},
  year={1988},
  volume={32 2},
  pages={217-27}
}
We report a case of acute leukemia in which studies at presentation showed both myeloid and lymphoid cell surface markers. At relapse membrane markers studies were consistent with a leukemia of B-lymphoid lineage. However, immunoglobulin (Ig) and T cell receptor (TCR) beta chain genes were both found in a rearranged configuration. The majority of metaphases… CONTINUE READING