The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

  title={The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups},
  author={Christina Curtis and Sohrab P. Shah and Suet-Feung Chin and Gulisa Turashvili and Oscar M. Rueda and Mark J Dunning and Doug Speed and Andrew G Lynch and Shamith A. Samarajiwa and Yinyin Yuan and Stefan Gr{\"a}f and Gavin Ha and Gholamreza Haffari and Ali Bashashati and Roslin Russell and Steven McKinney and Anita Langer\od and Andrew R. Green and Elena Provenzano and Gordon C. Wishart and Sarah E. Pinder and Peter Hamilton Watson and Florian Markowetz and Leigh C. Murphy and Ian O. Ellis and Arnie Purushotham and Anne-Lise B\orresen-Dale and James D. Brenton and Simon Tavar{\'e} and Carlos Caldas and Samuel Aparicio},
The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We present an integrated analysis of copy number and gene expression in a discovery and validation set of 997 and 995 primary breast tumours, respectively, with long-term clinical follow-up. Inherited variants (copy number variants and single nucleotide polymorphisms) and acquired somatic copy number aberrations (CNAs) were… CONTINUE READING
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