• DOI:10.1038/nature01554
• Corpus ID: 4335895

The genome sequence of the filamentous fungus Neurospora crassa

@article{Galagan2003TheGS,
  title={The genome sequence of the filamentous fungus Neurospora crassa},
  author={James E. Galagan and Sarah E. Calvo and Katherine A. Borkovich and Eric U. Selker and Nick D Read and David B. Jaffe and William W. Fitzhugh and Li‐Jun Ma and Sergei Smirnov and Seth Purcell and Bushra Rehman and Timothy Elkins and Reinhard Engels and Shunguang Wang and Cydney B. Nielsen and Jonathan Butler and Matthew G. Endrizzi and D. W. Qui and Peter Ianakiev and Deborah Bell-Pedersen and Mary Anne Nelson and Margaret Werner-Washburne and Claude P. Selitrennikoff and John A. Kinsey and Edward L. Braun and Alex Zelter and Ulrich Schulte and Gregory O. Kothe and Gregory Jedd and Werner Mewes and Chuck Staben and Edward M. Marcotte and David Greenberg and Alice Roy and Karen Foley and Jerome W. Naylor and Nicole Stange-thomann and Robert Barrett and Sante Gnerre and Michael Kamal and Manolis Kamvysselis and Evan Mauceli and C. Bielke and Stephen Rudd and Dmitrij Frishman and Svetlana Kry{\vs}tofov{\'a} and Carolyn G. Rasmussen and Robert L. Metzenberg and David D. Perkins and Scott Kroken and Carlo Cogoni and Giuseppe Macino and David E. A. Catcheside and Weixi Li and Robert J. Pratt and Stephen A Osmani and Colin P. C. DeSouza and Louis Glass and Marc J. Orbach and J. Andrew Berglund and Rodger B. Voelker and Oded Yarden and Michael D. Plamann and Stephan Seiler and Jay C. Dunlap and Alan Radford and Rodolfo Aramayo and Donald O. Natvig and Lisa A. Alex and Gertrud Mannhaupt and Daniel J. Ebbole and Michael Freitag and Ian T. Paulsen and Matthew S. Sachs and Eric S. Lander and Chad Nusbaum and Bruce W. Birren},
  journal={Nature},
  year={2003},
  volume={422},
  pages={859-868}
}

• J. Galagan, S. Calvo, +74 authors B. Birren
• Published 24 April 2003
• Biology
• Nature

Neurospora crassa is a central organism in the history of twentieth-century genetics, biochemistry and molecular biology. Here, we report a high-quality draft sequence of the N. crassa genome. The approximately 40-megabase genome encodes about 10,000 protein-coding genes—more than twice as many as in the fission yeast Schizosaccharomyces pombe and only about 25% fewer than in the fruitfly Drosophila melanogaster. Analysis of the gene set yields insights into unexpected aspects of Neurospora biology including the identification of genes potentially associated with red light photobiology, genes implicated in secondary metabolism, and important differences in Ca2+ signalling as compared with plants and animals. Neurospora possesses the widest array of genome defence mechanisms known for any eukaryotic organism, including a process unique to fungi called repeat-induced point mutation (RIP). Genome analysis suggests that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes.