The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease.

  title={The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease.},
  author={Najib M El-Sayed and Peter J. Myler and Daniella C. Bartholomeu and Daniel Nilsson and Gautam Aggarwal and Anh-Nhi Tran and Elodie Ghedin and Elizabeth A. Worthey and Arthur L. Delcher and Ga{\"e}lle Blandin and Scott J. Westenberger and Elisabet Caler and Gustavo C. Cerqueira and Carole Branche and Brian Haas and Atashi Anupama and Erik Arner and Lena {\AA}slund and Philip Attipoe and Esteban J Bontempi and Fr{\'e}d{\'e}ric Bringaud and P. Burton and Eithon Cadag and David A. Campbell and Mark Carrington and Jonathan Crabtree and Hamid Darban and Jos{\'e} Franco da Silveira and Pieter A de Jong and Kimberly Edwards and Paul T. Englund and Gholam Fazelina and Tamara V. Feldblyum and Marcela Ferella and Alberto Carlos C Frasch and Keith Gull and David Horn and Li-hua Hou and Yiting Huang and Ellen Kindlund and Michele M. Klingbeil and Sindy Kluge and Hean Koo and Daniela R. Lacerda and Mariano Jorge Levin and Hernan A Lorenzi and Tin Louie and Carlos Renato Machado and Richard McCulloch and Alan McKenna and Yumi Mizuno and Jeremy C Mottram and Siri O Nelson and Stephen Ochaya and Kazutoyo Osoegawa and Grace H Pai and Marilyn Parsons and Martin Pentony and U. Pettersson and Mihai Pop and Jose L. Ramirez and Joel Rinta and Laura Robertson and Steven L Salzberg and Daniel S{\'a}nchez and Amber Seyler and Reuben Sunil-Kumar Sharma and Jyoti Shetty and Anjana J. Simpson and Ellen Sisk and Martti T. Tammi and Rick L. Tarleton and Santuza Maria Ribeiro Teixeira and Susan E Van Aken and Christy Vogt and Pauline N Ward and Bill Wickstead and Jennifer R. Wortman and O. White and Claire M. Fraser and Kenneth D. Stuart and Bj{\"o}rn Andersson},
  volume={309 5733},
Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T… CONTINUE READING
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