The genome phylogeny of domestic cat, red panda and five mustelid species revealed by comparative chromosome painting and G-banding

  title={The genome phylogeny of domestic cat, red panda and five mustelid species revealed by comparative chromosome painting and G-banding},
  author={Wenhui Nie and Jinhuan Wang and Patricia Caroline Mary O’Brien and Beiyuan Fu and Tian Ying and Malcolm Andrew Ferguson-Smith and Fengtang Yang},
  journal={Chromosome Research},
Genome-wide homology maps among stone marten (Martes foina, 2n = 38), domestic cat (Felis catus, 2n = 38), American mink (Mustela vison, 2n = 30), yellow-throated marten (Martes flavigula, 2n = 40), Old World badger (Meles meles, 2n = 44), ferret badger (Melogale moschata, 2n = 38) and red panda (Ailurus fulgens, 2n = 36) have been established by cross-species chromosome painting with a complete set of stone marten probes. In total, 18 stone marten autosomal probes reveal 20, 19, 21, 18 and 21… 

Chromosome evolution in bears: reconstructing phylogenetic relationships by cross-species chromosome painting

The chromosomal painting results show that the African lion and clouded leopard have an identical karyotype which, in turn, is similar to that previously published for the cat (Felis catus, FCA 2n=38), confirming and extending other studies that show felids to be karyotypically conserved.

The ancestral carnivore karyotype (2n = 38) lives today in ringtails.

The patterns of chromosome segment homology among Carnivore species allowed us to reconstruct and propose the disposition of a high-resolution banded ancestral carnivore karyotype (ACK), suggesting that the ACK chromosome number would be 38, rather than the previously supposed 42.

Evolution of Genome Organizations of Squirrels (Sciuridae) Revealed by Cross-Species Chromosome Painting

With complete sets of chromosome-specific painting probes derived from flow-sorted chromosomes of human and grey squirrel (Sciurus carolinensis), the whole genome homologies between human and

Cross-species chromosome painting unveils cytogenetic signatures for the Eulipotyphla and evidence for the polyphyly of Insectivora

A shared human segmental combination, HSA 4/20, that could phylogenetically unite the Eulipotyphlan (i.e., the core insectivores) species is revealed.

Karyotype relationships of six bat species (Chiroptera, Vespertilionidae) from China revealed by chromosome painting and G-banding comparison

The results show that Robertsonian translocation is the main mode of karyotype evolution in Vespertilionidae and that the addition of heterochromatic material also plays an important role in the karyotypic evolution of the genera Tylonycteris and Nyctalus.

Phylogenomics of the dog and fox family (Canidae, Carnivora) revealed by chromosome painting

The results allow the formulation of a likely Canidae ancestral karyotype (CAK, 2n = 82), and reveal that at least 6–24 chromosomal fission/fusion events are needed to convert the CAK karyotypes of the modern canids.

Karyotypic relationships of horses and zebras: results of cross-species chromosome painting

The comparative maps of equids allow for the unequivocal characterization of chromosomal rearrangements that differentiate the karyotypes of these equid species.

Karyotypic conservatism in the suborder Feliformia (Order Carnivora)

The comparative chromosome painting data have enabled the integration of the hyena and palm civet chromosomes into the previously established comparative map among the domestic cat, domestic dog, American mink and human and improved the understanding on the karyotype phylogeny of Feliformia species.

New insights into the karyotypic relationships of Chinese muntjac (Muntiacus reevesi), forest musk deer (Moschus berezovskii) and gayal (Bos frontalis)

The results substantiate that chromosomes 1–5 and 11 of Chinese muntjac originated through exclusive centromere-to-telomere fusions of ancestral acrocentric chromosomes.

Chromosomal rearrangements and karyotype evolution in carnivores revealed by chromosome painting

Cross-species painting with dog probes is extended to seven more species representing six carnivore families, giving further insight into genome evolution and karyotype phylogenetic relationships among carnivores, and will facilitate the transfer of gene mapping data from human, domestic dog and cat to other species.



[Comparative chromosome painting shows the red panda (Ailurus fulgens) has a highly conserved karyotype].

We have established a comparative chromosome map between red panda (Ailurus fulgens, 2n = 36) and dog by chromosome painting with biotin-labelled chromosome-specific probes of the dog. Dog probes

Phylogenetic implications of the 38 putative ancestral chromosome segments for four canid species

Results show that the raccoon dog does not share a single biarmed autosome in common with the Arctic fox, red fox, or domestic cat, andComparative analysis of the distribution patterns of conserved chromosome segments revealed by dog paints in the genomes of the canids, cats, and human reveals 38 ancestral autosome segments.

Comparative genomics: tracking chromosome evolution in the family Ursidae using reciprocal chromosome painting

The different pSCEUS combinations occurring among modern bear species support and extend the postulated sequence of chromosomal rearrangements and provide a framework to propose patterns of genome reorganization among carnivores and other mammal radiations.

Conservation of human vs. feline genome organization revealed by reciprocal chromosome painting.

The results suggest that reciprocal chromosome painting will help reconstruct the history of genomic changes by determining the polarity of chromosomal rearrangements and establishing the ancestral karyotype for each principle branching point in mammalian evolution.

Genomic homology of the domestic ferret with cats and humans

The chromosome painting data indicate that the ferret has a highly conserved karyotypes closer to the ancestral carnivore karyotype than that of the cat, and an index of genomic diversity, Z, based on the relative number of conserved whole chromosome and chromosome segments as a preliminary statistic for rapid comparison between species.

Reciprocal chromosome painting illuminates the history of genome evolution of the domestic cat, dog and human

Comparative analysis of the distribution patterns of conserved segments defined by dog paints on cat and human chromosomes has refined the human/cat comparative genome map and has revealed 15 cryptic inversions in seven large chromosomal regions of Conserved synteny between humans and cats.

Conserved regions of homologous G-banded chromosomes between orders in mammalian evolution: carnivores and primates.

  • W. NashS. O’Brien
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1982
A comparison of homologous (by linkage criteria) chromosomes by using conventionally extended and high-resolution G-banding of human and feline chromosomes is presented and five subchromosomal regions (homologous to human chromosome 1p, 2p,2q, 12, and X) were found to be conserved and homologously by all the stated criteria.

Mapping Chromosomal Homologies Between Humans and Two Langurs (Semnopithecus Francoisi and S. Phayrei) by Chromosome Painting

Comparison of the hybridization patterns of human painting probes on these two langurs with the data on other Old World primates suggests that reciprocal and Robertsonian translocations as will as inversions could have occurred since the divergence of human and the langurs from a common ancestor.

ZOO-FISH analysis: cat and human karyotypes closely resemble the putative ancestral mammalian karyotype

It would appear that during evolution to the human karyotype the status quo has been conserved for at least some 100–120 million years and there has been no need to alter the well-balanced gene arrangement of the mammalian founder karyotypes.

A complete comparative chromosome map for the dog, red fox, and human and its integration with canine genetic maps.

The dog-fox map and DAPI banding comparison demonstrate that the remarkable karyotype differences between fox and dog are due to 26 chromosomal fusion events and 4 fission events and are proposed that the more easily karyotyped fox chromosomes can be used as a common reference and control system for future gene mapping in the DogMap project and CGH analysis of canine tumor DNA.