The genome-packaging signal of the influenza A virus genome comprises a genome incorporation signal and a genome-bundling signal.

@article{Goto2013TheGS,
  title={The genome-packaging signal of the influenza A virus genome comprises a genome incorporation signal and a genome-bundling signal.},
  author={Hideo Goto and Yukiko Muramoto and Takeshi Noda and Yoshihiro Kawaoka},
  journal={Journal of virology},
  year={2013},
  volume={87 21},
  pages={11316-22}
}
The influenza A virus genome comprises eight single-stranded negative-sense RNA segments (vRNAs). All eight vRNAs are selectively packaged into each progeny virion via so-called segment-specific genome-packaging signal sequences that are located in the noncoding and terminal coding regions of both the 3' and the 5' ends of the vRNAs. However, it remains unclear how these signals ensure that eight different vRNAs are packaged. Here, by using a reverse genetics system, we demonstrated that, in… CONTINUE READING

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