The genome of the blood fluke Schistosoma mansoni

  title={The genome of the blood fluke Schistosoma mansoni},
  author={Matthew Berriman and Brian J. Haas and Philip T. Loverde and R Alan Wilson and Gary P. Dillon and Gustavo Coutinho Cerqueira and Susan T. Mashiyama and Bissan Al-Lazikani and Luiza Freire Andrade and Peter D. Ashton and Martin Aslett and Daniella C. Bartholomeu and Gaelle Blandin and Conor R. Caffrey and Avril Coghlan and Richard M. R. Coulson and Tim Day and Art Delcher and Ricardo DeMarco and Appoliniare Djikeng and T. Eyre and John A. Gamble and Elodie Ghedin and Yong Xi Gu and Christiane Hertz-Fowler and Hirohisha Hirai and Yuriko Hirai and Robin Houston and Alasdair Ivens and David A. Johnston and Daniela R. Lacerda and Camila de C{\'a}ssia Macedo and Paul McVeigh and Zemin Ning and Guilherme C. Oliveira and John P. Overington and Julian Parkhill and Mihaela Pertea and Raymond J. Pierce and Anna V. Protasio and Michael A. Quail and Marie-Ad{\`e}le Rajandream and Jane Rogers and M. Sajid and Steven L Salzberg and Mario Stanke and Adrian Tivey and Owen White and David L Williams and Jennifer R. Wortman and Wenjie Wu and M. Kiumarse Zamanian and Adhemar Zerlotini and Claire Fraser-Liggett and Barclay G. Barrell and Najib M El-Sayed},
Schistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that affects 210 million people in 76 countries. Here we present analysis of the 363 megabase nuclear genome of the blood fluke. It encodes at least 11,809 genes, with an unusual intron size distribution, and new families of micro-exon genes that undergo frequent alternative splicing. As the first sequenced flatworm, and a representative of the Lophotrochozoa, it offers insights into early events in the… CONTINUE READING
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