The genome of murine cytomegalovirus is shaped by purifying selection and extensive recombination.

@article{Smith2013TheGO,
  title={The genome of murine cytomegalovirus is shaped by purifying selection and extensive recombination.},
  author={Lee M. Smith and Andrea R. McWhorter and Geoffrey R. Shellam and Alec J Redwood},
  journal={Virology},
  year={2013},
  volume={435 2},
  pages={258-68}
}
The herpesvirus lifestyle results in a long-term interaction between host and invading pathogen, resulting in exquisite adaptation of virus to host. We have sequenced the genomes of nine strains of murine cytomegalovirus (a betaherpesvirus), isolated from free-living mice trapped at locations separated geographically and temporally. Despite this separation these genomes were found to have low levels of nucleotide variation. Of the more than 160 open reading frames, almost 90% had a dN/dS ratio… CONTINUE READING

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