The genome of Plasmodium falciparum encodes an active delta-aminolevulinic acid dehydratase.

@article{Sato2002TheGO,
  title={The genome of Plasmodium falciparum encodes an active delta-aminolevulinic acid dehydratase.},
  author={Shigeharu Sato and Robert J. M. Wilson},
  journal={Current genetics},
  year={2002},
  volume={40 6},
  pages={391-8}
}
The enzyme delta-aminolevulinic acid dehydratase (ALAD) catalyses the second reaction in the heme biosynthetic pathway. It has been suggested previously that the malaria parasite Plasmodium falciparum imports this enzyme from the host cell for de novo heme biosynthesis. However, the parasite's genome encodes an orthologue for ALAD. Here we report molecular cloning of a complete cDNA for the parasite's intrinsic ALAD and show it rescues an ALAD-null mutant of Escherichia coli, indicating that… CONTINUE READING

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