The genome of HSV-1 translocates through the nuclear pore as a condensed rod-like structure.

@article{Shahin2006TheGO,
  title={The genome of HSV-1 translocates through the nuclear pore as a condensed rod-like structure.},
  author={Victor Shahin and Wali Hafezi and Hans Oberleithner and Yvonne Ludwig and Barbara Windoffer and Hermann Schillers and Joachim E. K{\"u}hn},
  journal={Journal of cell science},
  year={2006},
  volume={119 Pt 1},
  pages={
          23-30
        }
}
Incoming herpes simplex virus type-1 (HSV-1) capsids are known to dock to the nuclear pore complex (NPC) and release their genome. It has remained elusive, however, how the huge viral DNA translocates through the comparatively small NPC channel. In the present study, the interaction of HSV-1 with NPCs was analyzed by atomic force microscopy. In addition to capsids, smaller subviral structures--most with a diameter of 35-40 nm and a length of 130-160 nm--were visualized at the cytoplasmic side… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 36 REFERENCES

Evidence for Ca2+- and ATP-sensitive peripheral channels in nuclear pore complexes.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2001
VIEW 7 EXCERPTS

Nuclear import of viral DNA genomes.

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL