The genetics of systemic lupus erythematosus and implications for targeted therapy.

@article{Sestak2011TheGO,
  title={The genetics of systemic lupus erythematosus and implications for targeted therapy.},
  author={Andrea L. Sestak and Barbara G F{\"u}rnrohr and John Barker Harley and Joan Tenenbaum Merrill and Bahram Namjou},
  journal={Annals of the rheumatic diseases},
  year={2011},
  volume={70 Suppl 1},
  pages={i37-43}
}
Observations of familial aggregation (λs=8-29) and a 40% identical twin concordance rate prompted recent work towards a comprehensive genetic analysis of systemic lupus erythematosus (SLE). Since 2007, the number of genetic effects known to be associated with human lupus has increased by fivefold, underscoring the complexity of inheritance that probably contributes to this disease. Approximately 35 genes associated with lupus have either been replicated in multiple samples or are near the… CONTINUE READING

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