The genetics of sensory gating deficits in schizophrenia.

  title={The genetics of sensory gating deficits in schizophrenia.},
  author={Robert Freedman and Ann Olincy and Randal Glenn Ross and Merilyne C. Waldo and Karen E. Stevens and Lawrence E. Adler and Sherry Leonard},
  journal={Current psychiatry reports},
  volume={5 2},
Sensory gating abnormalities are an early clinical symptom of schizophrenia, and are characterized by a decrease in the brain's normal ability to inhibit the response to unimportant stimuli. Patients appear hypervigilant and have difficulty focusing their attention. A neurobiologic mechanism involved in these difficulties is nicotinic cholinergic modulation of inhibitory neuronal activity in the hippocampus. One measure of sensory gating abnormalities, diminished inhibition of the P50 evoked… CONTINUE READING


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