The genetics of selective serotonin reuptake inhibitors.

  title={The genetics of selective serotonin reuptake inhibitors.},
  author={Yvet Kroeze and Huiqing Zhou and Judith R Homberg},
  journal={Pharmacology & therapeutics},
  volume={136 3},
Selective serotonin reuptake inhibitors (SSRIs) are among the most widely prescribed drugs in psychiatry. Based on the fact that SSRIs increase extracellular monoamine levels in the brain, the monoamine hypothesis of depression was introduced, postulating that depression is associated with too low serotonin, dopamine and noradrenaline levels. However, several lines of evidence indicate that this hypothesis is too simplistic and that depression and the efficacy of SSRIs are dependent on… CONTINUE READING


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