The genetics of schizophrenia: glutamate not dopamine?

  title={The genetics of schizophrenia: glutamate not dopamine?},
  author={David A. Collier and Tao Li},
  journal={European journal of pharmacology},
  volume={480 1-3},
The major targets of current drugs used in mental health, such as neurotransmitter receptors and transporters, are based on serendipitous findings from several decades ago, and there is currently a severe drought of new drug targets. There is a pressing need for novel drugs, and much hope has been placed on the use of molecular genetics to help define them. However, despite evidence for a genetic basis to schizophrenia stretching back for over a century, and a heritability of about 80%, the… CONTINUE READING


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