The genetics of psoriasis and autoimmunity.

  title={The genetics of psoriasis and autoimmunity.},
  author={Anne M Bowcock},
  journal={Annual review of genomics and human genetics},
  • Anne M Bowcock
  • Published 2005 in Annual review of genomics and human genetics
Psoriasis is an inflammatory/autoimmune disease and, as with many autoimmune diseases, is associated with alleles from the major histocompatibility complex (MHC). With psoriasis and autoimmune disease, the penetrance of the MHC-associated alleles is never 100%, even for monozygotic twins. This may be because development requires additional environmental and/or genetic modifiers or requires specific T-cell receptor arrangements. Families segregating single or multilocus susceptibility alleles… CONTINUE READING

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