The genetics of proteasomes and antigen processing.

  title={The genetics of proteasomes and antigen processing.},
  author={John J. Monaco and Dipankar Nandi},
  journal={Annual review of genetics},
The T cell arm of the immune system of higher vertebrates is specific for antigenic peptides bound to cell surface major histocompatibility complex (MHC) molecules. These peptides are derived from two distinct pathways of antigen processing. The class I, or endogenous pathway, utilizes proteasomes and the ubiquitin system for protein degradation, with subsequent transport of the resulting peptides into the lumen of the endoplasmic reticulum by a specific peptide transporter, called TAP. The… CONTINUE READING


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