The genetics of multiple sclerosis: SNPs to pathways to pathogenesis

Abstract

Multiple sclerosis (MS) is an autoimmune demyelinating disease and a common cause of neurological disability in young adults. The modest heritability of MS reflects complex genetic effects and multifaceted gene–environment interactions. The human leukocyte antigen (HLA) region is the strongest susceptibility locus for MS, but a genome-wide association study… (More)
DOI: 10.1038/nrg2395

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