The genetics of melanoma: recent advances.

  title={The genetics of melanoma: recent advances.},
  author={Victoria K. Hill and Jared J. Gartner and Yardena Samuels and Alisa M. Goldstein},
  journal={Annual review of genomics and human genetics},
Cutaneous malignant melanoma results from the interplay of genetic, host, and environmental factors. Genetic factors implicated in melanoma etiology include inherited high-, intermediate-, and low-risk susceptibility genes as well as numerous somatic mutations in melanoma tumors. CDKN2A is the major high-risk melanoma susceptibility gene identified to date. Recent identification of low-risk loci has been accomplished predominantly through genome-wide association studies. Whole-exome and whole… 

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