The genetics of eating disorders.

@article{Trace2013TheGO,
  title={The genetics of eating disorders.},
  author={Sara E. Trace and Jessica H Baker and Eva Mar{\'i}a Pe{\~n}as-Lled{\'o} and Cynthia M. Bulik},
  journal={Annual review of clinical psychology},
  year={2013},
  volume={9},
  pages={
          589-620
        }
}
Over the past decade, considerable advances have been made in understanding genetic influences on eating pathology. Eating disorders aggregate in families, and twin studies reveal that additive genetic factors account for approximately 40% to 60% of liability to anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). Molecular genetics studies have been undertaken to identify alterations in deoxyribonucleic acid sequence and/or gene expression that may be involved in the… 
Genetics of Eating Disorders
Disordered eating behavior is the core symptom of the complex disorders anorexia nervosa and bulimia nervosa. Twin and family studies derive high heritability estimates. Hence, substantial genetic
Genetics and Epigenetics of Eating Disorders.
TLDR
The diagnostic criteria, clinical features, prevalence, and prognosis of AN, BN, and BED are reviewed, followed by a review of family, twin, and adoption studies and the history of genetic studies of EDs is reviewed.
Molecular Genetics of Eating Disorders
TLDR
Information gleaned from large-scale genetic studies of other psychiatric and medical disorders indicate that even larger sample sizes, as well as use of emerging genomic approaches, in combination with environmental risk factors, are needed to fully elucidate the aetiology of eating disorders.
Discussing the putative role of obesity-associated genes in the etiopathogenesis of eating disorders.
TLDR
In the present work, the few existing studies, but also indications and biological concepts that point to genes in the CNS as good candidates for association studies with eating disorder patients are reviewed.
Genetic risk factors for eating disorders: an update and insights into pathophysiology
TLDR
Important findings derived from formal and molecular genetics are reviewed in order to outline a genetics-based pathophysiological model of eating disorders, which takes into account environmental and nutritional factors, genetic factors related to the microbiome, the metabolic and endocrine system, the immune system, and the brain, in addition to phenotypical traits of EDs.
Genetics of Anorexia Nervosa
TLDR
This review synthesizes the current state of knowledge about the genetic etiology of anorexia nervosa, provides directions for future research, and discusses clinical implications for this research.
[Genetics factors in pathogenesis and clinical genetics of binge eating disorder].
TLDR
The results confirmed the genetic and pathogenic originality of BED as a separate psychopathological phenomenon, but not a subtype of obesity, and the ability to identify the subphenotypes of B ED on genetic basis involving clinical criteria.
A Primer on the Genetics of Comorbid Eating Disorders and Substance Use Disorders.
TLDR
Research investigating binge eating and inappropriate compensatory behaviours using emerging statistical genetic methods, as well as examining gene-environment interplay, will provide important clues into the aetiology of comorbid EDs and SUDs.
Genetics and Epigenetics of Eating Disorders.
TLDR
The foremost goal of current genetic research on eating disorders is to identify all loci and pathways that confer risk or protection and to use identified loci to inform prevention and treatment approaches.
Genetic Vulnerability to Eating Disorders and Substance Use Disorders
TLDR
This chapter reviews the current empirical literature indicating that anorexia nervosa and bulimia nervosa, and a variety of substance use disorders are influenced by genetic factors, as well as preliminary findings exploring whether these disorders indeed share a genetic architecture.
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