The genetics of diabetes susceptibility in mice.

  title={The genetics of diabetes susceptibility in mice.},
  author={Edward H. Leiter},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={3 11},
  • Edward H. Leiter
  • Published 1989 in
    FASEB journal : official publication of the…
The factors associated with a diabetes-susceptible genotype in mice exhibiting various forms of heritable glucose intolerance syndromes are discussed. Genetic models of insulin-dependent and non-insulin-dependent diabetes in mice are described. Although single gene mutations can be defined for each model that are major contributors to diabetogenic stress, polygenic interactions are required for the expression of a diabetic phenotype, and environmental factors are also contributory. Several… CONTINUE READING