The genetics of breast cancer risk in the post-genome era: thoughts on study design to move past BRCA and towards clinical relevance

@inproceedings{Skol2016TheGO,
  title={The genetics of breast cancer risk in the post-genome era: thoughts on study design to move past BRCA and towards clinical relevance},
  author={Andrew D. Skol and Mark M. Sasaki and Kenan Onel},
  booktitle={Breast Cancer Research},
  year={2016}
}
More than 12 % of women will be diagnosed with breast cancer in their lifetime. Although there have been tremendous advances in elucidating genetic risk factors underlying both familial and sporadic breast cancer, much of the genetic contribution to breast cancer etiology remains unknown. The discovery of BRCA1 and BRCA2 over 20 years ago remains the seminal event in the field and has paved the way for the discovery of other high-penetrance susceptibility genes by linkage analysis. The advent… CONTINUE READING
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