The genetics of adiponectin

@article{Vasseur2003TheGO,
  title={The genetics of adiponectin},
  author={Francis Vasseur and Frédéric Leprêtre and Corinne Lacquemant and Philippe Froguel},
  journal={Current Diabetes Reports},
  year={2003},
  volume={3},
  pages={151-158}
}
Adiponectin encoded by the APM1 gene is one of the adipocyte-expressed proteins that function in the homeostatic control of glucose, lipid, and energy metabolism. Its dysregulation has been suggested to be involved in disorders covering the metabolic X syndrome, such as insulin resistance, obesity, type 2 diabetes, and coronary artery disease. Recent data present evidence of a genetic modulation of the adiponectin level, and linkage of the 3q27 locus, where the APM 1 gene lies, with diabetes… 
Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies
TLDR
The adiponectin-encoding gene, ADIPOQ (ACDC), is very polymorphic: many frequent exonic synonymous, intronic and promoter single-nucleotide polymorphisms (SNPs) have been identified, as well as a few rare exonic amino acid substitutions.
Adiponectin – journey from an adipocyte secretory protein to biomarker of the metabolic syndrome
TLDR
Evidence for this relationship will include how decreased levels of plasma adiponectin are associated with increased body mass index (BMI), decreased insulin sensitivity, less favourable plasma lipid profiles, increased levels of inflammatory markers and increased risk for the development of cardiovascular disease.
Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance.
TLDR
The two alleles of a SNP in the 3' untranslated region were expressed unequally, and ADIPOR1 mRNA levels were significantly lower among transformed lymphocytes from diabetic African-American individuals than among control cell lines, which might suggest a role for ADIPor1 in the metabolic syndrome.
Adiponectin in childhood.
  • A. Jeffery, M. Murphy, T. Wilkin
  • Medicine, Biology
    International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity
  • 2008
TLDR
Clear links between adiponectin and features of the metabolic syndrome in obese children and adolescents are demonstrated and its role as a predictor of metabolic dysfunction in healthy, normal-weight youngsters is less clear.
ACDC/Adiponectin and PPAR‐γ Gene Polymorphisms: Implications for Features of Obesity
TLDR
Polymorphisms in the ACDC gene are associated with body fat distribution, whereas the Pro12Ala polymorphism in PPAR-γ is associated with overall adiposity, apparently in interaction with an ACDC promoter SNP.
Study of Adiponectin gene polymorphism among off springs of Type 2 Diabetes mellitus
TLDR
It was found that there was statistically significant association of T>G allele in cases than in control, the p value was <0.001, therefore, SNP45T>G in adiponectin gene may be one of the risk factors for type 2 diabetes.
An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance.
TLDR
The findings indicate that serum adiponectin levels are associated with several components of the metabolic syndrome (MS), and the SNP276 of the adiponECTin gene may affect impaired glucose tolerance and hypoadiponectinemia.
Adiponectin: Novelties in Metabolism and Hormonal Regulation
TLDR
Data show adiponectin to be an important factor in the issue of obesity and its associated disorders, and indicate a potential future utilization of adip onectin as a drug in the treatment of metabolic syndrome.
...
...

References

SHOWING 1-10 OF 59 REFERENCES
Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome.
TLDR
The findings suggest that I164T mutation is associated with low plasma adiponectin concentration and type 2 diabetes.
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
TLDR
It is concluded that decreased adiponectin is implicated in the development of insulin resistance in mouse models of both obesity and lipoatrophy and that the replenishment of adiponECTin might provide a novel treatment modality for insulin resistance and type 2 diabetes.
A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome.
TLDR
It is concluded that variability at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome, but given the nature of the two SNPs, the risk haplotype is most probably a marker in linkage disequilibrium with an as yet unidentified polymorphism that affects plasma adip onectin levels and insulin sensitivity.
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
TLDR
Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adip onectin is secreted only from adipose tissue.
Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.
TLDR
Evidence of an association between frequent single nucleotide polymorphisms at positions 45 and 276 in the adiponectin gene and type 2 diabetes is presented, and the observation that adiponECTin improves insulin sensitivity in animal models is concluded.
The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome.
TLDR
These results identify quantitative trait loci with significant effects on a newly described, and potentially very important, adipocyte-derived protein and reveal the emergence of a consistent pattern of linkage results for obesity-related traits across a number of human populations.
Decreased plasma adiponectin concentrations in women with dyslipidemia.
TLDR
It is indicated that high-TGnemia and low-HDL-Cnemia are associated with low plasma adiponectin concentrations in nondiabetic women and further efforts must now be targeted to determine whether adip onectin causes these lipid abnormalities and thus whether it is partly responsible for the atherogenic risk seen in the metabolic syndrome.
The Peroxisome Proliferator-Activated Receptor-γ2 Pro12Ala Polymorphism
TLDR
The Pro12Ala polymorphism in PPAR-γ2 represents the first genetic variant with a broad impact on the risk of common type 2 diabetes and the precise understanding of its mechanism may lead to novel diagnostic, preventive, and therapeutic approaches for improving the management of type 2abetes.
Genomic structure and mutations in adipose-specific gene, adiponectin
TLDR
G/T polymorphism in exon 2 was associated with neither plasma adiponectin concentrations nor the presence of obesity, and a subject carrying missense mutation (R112C) showed markedly low plasma adip onectin concentration.
...
...