The genetics of adaptation: the roles of pleiotropy, stabilizing selection and drift in shaping the distribution of bidirectional fixed mutational effects.

@article{Griswold2003TheGO,
  title={The genetics of adaptation: the roles of pleiotropy, stabilizing selection and drift in shaping the distribution of bidirectional fixed mutational effects.},
  author={Cortland K. Griswold and Michael C Whitlock},
  journal={Genetics},
  year={2003},
  volume={165 4},
  pages={2181-92}
}
Pleiotropy allows for the deterministic fixation of bidirectional mutations: mutations with effects both in the direction of selection and opposite to selection for the same character. Mutations with deleterious effects on some characters can fix because of beneficial effects on other characters. This study analytically quantifies the expected frequency of mutations that fix with negative and positive effects on a character and the average size of a fixed effect on a character when a mutation… CONTINUE READING
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Effects of P the same amount of drift , stabilizing selection , and dielements on quantitative traits in Drosophila melanogaster

  • J. C. Larkin
  • Genetics rectional selection .
  • 1992

The effect of linkage on limits character and the increase in frequency of negative efto artificial selection

  • M. Kimura
  • Genet . Res .
  • 1966

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