The genetics of Kawasaki disease

@article{Onouchi2018TheGO,
  title={The genetics of Kawasaki disease},
  author={Yoshihiro Onouchi},
  journal={International Journal of Rheumatic Diseases},
  year={2018},
  volume={21}
}
  • Y. Onouchi
  • Published 2018
  • Biology, Medicine
  • International Journal of Rheumatic Diseases
Kawasaki disease (KD) is a complex disorder which affects genetically susceptible infants and children. Several susceptibility genes (e.g., ITPKC, CASP3, CD40 and ORAI) and chromosomal regions have been identified through genome‐wide association and genome‐wide linkage studies to have association with KD. Knowledge of susceptibility genes involved in the pathogenesis of KD may provide new insights into diagnosis and treatment of this condition. However, there is much that we still do not know… Expand
A framework for understanding Kawasaki disease pathogenesis.
TLDR
This review discusses recent hypotheses on KD pathogenesis as well as new insights into the innate immune response and mechanisms behind vascular damage, which suggest a strong genetic influence in racial predilection. Expand
Novel coronavirus infection and Kawasaki disease.
  • V. Bitsadze, K. Grigoreva, +4 authors A. Makatsariya
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2020
There is a global problem of increment of the number of children with clinical features that mimic Kawasaki Disease (KD) during the ongoing Coronavirus Disease 2019 (COVID-19) pandemic. The diseaseExpand
How Should We Classify Kawasaki Disease?
TLDR
A review of the evidences available up to now regarding an autoreactive hypothesis that Kawasaki disease is triggered by an antigen that shares homology with structures in the vascular wall, and molecular mimicry resulting in an immune response directed to that tissue. Expand
Kawasaki Disease
Kawasaki disease (KD) is the commonest cause of acquired heart disease in children in the developed world and is increasingly being reported from developing countries. KD has a predilection for theExpand
Antibodies and Immunity During Kawasaki Disease
  • M. Hicar
  • Medicine
  • Frontiers in Cardiovascular Medicine
  • 2020
TLDR
The role of humoral immunity in KD pathogenesis, treatment, and recovery is reviewed and it is shown that children with KD have similar plasmablast responses as other children with infectious diseases, further supporting an infectious starting point. Expand
Maternal Autoimmune Disorders and Risk of Kawasaki Disease in Offspring.
TLDR
It is found that maternal autoimmune disorders, especially autoimmune thyroiditis, may be risk factors for Kawasaki disease in children, particularly young children. Expand
Increased Risk of Kawasaki Disease in Infants Born of Mothers With Immune Disorders
TLDR
Maternal numbers of autoimmune disorders showed a dose-dependent relationship with KD incidence and children born from mothers with asthma and allergic rhinitis had a higher risk of developing KD. Expand
Kawasaki Syndrome: A Special View To New Entities Like MIS-C, PIMS and Kawasaki-Like Features In Covid-19 Disease With Recommendation of Classification
TLDR
A large number of genetic studies suggest an association between viral super antigens as the origin of Kawasaki disease, where streptococcal pyrogenic exotoxin and toxic shock syndrome toxin 1 play a favorite role. Expand
Perspective of Immunopathogenesis and Immunotherapies for Kawasaki Disease
TLDR
Further studies are proposed to delineate the immunopathogenesis of IVIG-resistance and KDSS, to identify high risk patients with genetic susceptibility, and to develop an ideal treatment regimen, such as by providing idiotypic immunoglobulins to curb cytokine storms, NO overproduction, and the epigenetic induction of Treg function. Expand
SARS-CoV-2 infection triggering recurrence of Kawasaki disease in a 10-year-old child
TLDR
It is possible that SARS-CoV-2 infection triggered the recurrence of KD in this child who might have been genetically predisposed to KD. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 50 REFERENCES
Common variants in CASP3 confer susceptibility to Kawasaki disease.
TLDR
It is reported that multiple variants in the caspase-3 gene (CASP3) that are in linkage disequilibrium confer susceptibility to KD in both Japanese and US subjects of European ancestry. Expand
Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis
TLDR
Two new loci are reported, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10−8) and may lead to a better understanding of the role of immune activation and inflammation in Kawasaki Disease pathogenesis. Expand
A genomewide linkage analysis of Kawasaki disease: evidence for linkage to chromosome 12
TLDR
This is the first large-scale study of the genetic susceptibility to Kawasaki disease, and the results could greatly promote research on identification of the molecular pathogenesis of KD. Expand
ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms
TLDR
A functional SNP (itpkc_3) in the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) gene on chromosome 19q13.2 that is significantly associated with Kawasaki disease susceptibility and also with an increased risk of coronary artery lesions is identified. Expand
Identification of Novel Susceptibility Loci for Kawasaki Disease in a Han Chinese Population by a Genome-Wide Association Study
TLDR
The novel KD candidates identified have been implicated in T cell receptor signaling, regulation of proinflammatory cytokines, as well as antibody-mediated immune responses and may lead to a better understanding of the underlying molecular pathogenesis of KD. Expand
Variations in ORAI1 Gene Associated with Kawasaki Disease
TLDR
Data indicate that ORAI1 gene variations are associated with KD and may suggest the potential importance of the Ca(2+)/NFAT pathway in the pathogenesis of this disorder. Expand
A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease
TLDR
Results implicate a locus in the 1p31 region and the PELI1 gene locu in the 2p13.3 region as susceptibility loci for KD and CALs, respectively. Expand
Responsible Genetic Factors for Vasculitis in Kawasaki Disease
TLDR
Despite more than 40 years of intensive research, the causative microorganism of KD remains unknown and epidemiological studies have revealed a significant role of genetic components in host susceptibility to KD pathogenesis. Expand
Genome-wide linkage and association mapping identify susceptibility alleles in ABCC 4 for Kawasaki disease
Background Kawasaki disease (KD) is a self limited vasculitis in which host genetics plays a prominent role. To further the understanding of the role of host genetics in KD, a three-stage geneticExpand
Genome-wide linkage and association mapping identify susceptibility alleles in ABCC4 for Kawasaki disease
TLDR
Genetic data suggest that ABCC4 could play a fundamental role in KD pathogenesis with effects on immune activation and vascular response to injury and validate findings from a recent KD genome-wide association study. Expand
...
1
2
3
4
5
...