The genetics of CD14 in allergic disease.

  title={The genetics of CD14 in allergic disease.},
  author={Gerard H Koppelman and Dirkje S Postma},
  journal={Current opinion in allergy and clinical immunology},
  volume={3 5},
PURPOSE OF REVIEW The 'hygiene hypothesis' implies that infections in early childhood prevent the development of atopy. Atopy is caused by the interaction of the environment with genetic factors. Therefore, both contacts with microbial products such as endotoxin as well as CD14, a gene involved in the immunological response to endotoxin, are discussed in… CONTINUE READING