The genetics and genomics of the silkworm, Bombyx mori.

@article{Goldsmith2005TheGA,
  title={The genetics and genomics of the silkworm, Bombyx mori.},
  author={Marian R Goldsmith and T. Shimada and Hiroaki Abe},
  journal={Annual review of entomology},
  year={2005},
  volume={50},
  pages={
          71-100
        }
}
We review progress in applying molecular genetic and genomic technologies to studies in the domesticated silkworm, Bombyx mori, highlighting its use as a model for Lepidoptera, and in sericulture and biotechnology. Dense molecular linkage maps are being integrated with classical linkage maps for positional cloning and marker-assisted selection. Classical mutations have been identified by a candidate gene approach. Cytogenetic and sequence analyses show that the W chromosome is composed largely… 
Genetic mapping of Z chromosome and identification of W chromosome-specific markers in the silkworm, Bombyx mori
TLDR
A genetic map of randomly amplified polymorphic DNA fragments (RAPD), simple sequence repeats (SSR), and fluorescent intersimple sequence repeat PCR (FISSR) markers for the Z chromosome is constructed using a backcross mapping population to identify and map sex-linked traits in the silkworm.
A Second-Generation Integrated Map of the Silkworm Reveals Synteny and Conserved Gene Order Between Lepidopteran Insects
TLDR
A second-generation linkage map was constructed for the silkworm, Bombyx mori, and found significant synteny and conserved gene order between B. mori and a nymphalid butterfly, Heliconius melpomene, in four linkage groups (LGs), strongly suggesting that using B.mori as a reference for comparative genomics in Lepidotera is highly feasible.
Highly Efficient Targeted Gene Disruption in the Silkworm, Bombyx mori, Using Genome Editing Tools
TLDR
This chapter summarizes recent advances in genome editing techniques in B. mori and proposes guidelines for experimental design and strategy for successful gene knockout experiments using this species.
Molecular Marker-Assisted Selection Breeding in Silkworm, Bombyx mori
TLDR
To keep up the pace with the technology, it has become necessary for the breeder to be familiar with the advancement in the field of DNA-marker technology and to turn into biotechnologists.
Horizontal gene transfer in silkworm, Bombyx mori
TLDR
The whole genome of B. mori is compared with those of 382 prokaryotic and eukaryotic species to investigate the potential horizontal gene transfer (HGT) genes and functional analysis revealed that several HGT candidate genes have added important characters, such as resistance to pathogen, to B.mori.
Genome editing in Bombyx mori: New opportunities for silkworm functional genomics and the sericulture industry
TLDR
The progress and potential of genome editing in silkworm and its applications in functional genomic studies for generating novel genetic materials are summarized.
Recent progress in genome engineering techniques in the silkworm, Bombyx mori
TLDR
TALENs can now be used as a standard tool for gene targeting studies, even when mutant phenotypes are unknown, and will greatly increase the usefulness of Bombyx as a model for lepidopteran insects, the major agricultural pests, and lead to sophisticated breeding of Bomberx for use in sericulture and biotechnology.
FLP Recombinase-Mediated Site-Specific Recombination in Silkworm, Bombyx mori
TLDR
It is concluded that the FLP/FRT system is a useful tool for genome manipulation in the silkworm and provides a useful reference for the establishment of genome manipulation technologies in other lepidopteran species.
Gene expression profile of the early embryonic gene of the silkworm, Bombyx mori
TLDR
A full-length cDNA library from silkworm’s eggs is constructed and analyzed for development of a useful genes that has a transcript expressional specificity in the early embry-onic stage of the silkworm, Bombyx mori.
Linkage Analysis of Bombyx mori Sex-controlled Melanism(sml) Mutation Using Morphological and Molecular Markers
TLDR
Results showed that sml gene was linked with molecular markers on the 17th linkage group(corresponding to chromosome 17), but was independent with morphological markers or molecular marker on the other linkage groups,Therefore, sml mutational gene is located on the17th chromosome of silkworm.
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