The genetic program of hematopoietic stem cells.

@article{Phillips2000TheGP,
  title={The genetic program of hematopoietic stem cells.},
  author={R. L. Phillips and Robin E. Ernst and Benjamin D. Brunk and Natalia Yordanova Ivanova and Mark A Mahan and Julia K Deanehan and Kateri Moore and G. Christian Overton and Ihor Lemischka},
  journal={Science},
  year={2000},
  volume={288 5471},
  pages={1635-40}
}
Blood cell production originates from a rare population of multipotent, self-renewing stem cells. A genome-wide gene expression analysis was performed in order to define regulatory pathways in stem cells as well as their global genetic program. Subtracted complementary DNA libraries from highly purified murine fetal liver stem cells were analyzed with bioinformatic and array hybridization strategies. A large percentage of the several thousand gene products that have been characterized… CONTINUE READING

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