The genetic modifier Rpe65Leu(450): effect on light damage susceptibility in c-Fos-deficient mice.

PURPOSE To test whether introduction of the Rpe65Leu(450) variant can overcome protection against light-induced photoreceptor apoptosis in mice without the activator protein (AP)-1 constituent c-Fos. METHODS c-Fos-deficient mice (c-fos(-/-)) carrying the Leu(450) variant of RPE65 were compared with c-fos(-/-) mice with Rpe65Met(450). Expression of RPE65… CONTINUE READING