The genetic landscape of a cell.

@article{Costanzo2010TheGL,
  title={The genetic landscape of a cell.},
  author={Michael Costanzo and Anastasia Baryshnikova and Jeremy Bellay and Yungil Kim and Eric D. Spear and Carolyn S Sevier and Huiming Ding and Judice L. Y. Koh and Kiana Toufighi and Sara Mostafavi and Jeany Prinz and Robert P St Onge and Benjamin VanderSluis and Taras Makhnevych and Franco J. Vizeacoumar and Solmaz Alizadeh and Sondra Bahr and Ren{\'e}e L. Brost and Yiqun Chen and Murat Cokol and Raamesh Deshpande and Zhijian Li and Zhen-Yuan Lin and Wendy Liang and Michaela M{\aa}rback and Jadine Paw and Bryan-Joseph San Luis and Ermira Shuteriqi and Amy Hin Yan Tong and Nydia van Dyk and Iain Michael Wallace and Joseph Andrew Whitney and Matthew T. Weirauch and Guoqing Zhong and Hongwei Zhu and Walid A. Houry and Michael Brudno and Sasan Ragibizadeh and Bal{\'a}zs Papp and Csaba P{\'a}l and Frederick P. Roth and Guri Giaever and Corey Nislow and Olga G. Troyanskaya and Howard A Bussey and Gary D. Bader and Anne-Claude Gingras and Quaid Morris and Philip M. Kim and Chris A. Kaiser and Chad L. Myers and Brenda J. Andrews and Charles Boone},
  journal={Science},
  year={2010},
  volume={327 5964},
  pages={425-31}
}
A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles for approximately 75% of all genes in the budding yeast, Saccharomyces cerevisiae. A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to… CONTINUE READING
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