The genetic interaction between VKORC1 c1173t and calumenin a29809g modulates the anticoagulant response of acenocoumarol.

@article{GonzlezConejero2007TheGI,
  title={The genetic interaction between VKORC1 c1173t and calumenin a29809g modulates the anticoagulant response of acenocoumarol.},
  author={Roc{\'i}o Gonz{\'a}lez-Conejero and Javier Corral and Vanessa Rold{\'a}n and Fernendo Ferrer and Ibis S{\'a}nchez-Serrano and Jos{\'e} Javier S{\'a}nchez-Blanco and F. Mar{\'i}n and Vicente Vicente},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2007},
  volume={5 8},
  pages={1701-6}
}
BACKGROUND The efficacy of oral anticoagulant therapy is largely conditioned by both environmental and genetic factors. OBJECTIVES To attempt to define the genetic profile involved in the response to this treatment. PATIENTS AND METHODS We selected 100 men younger than 75 years, with non-valvular atrial fibrillation, who started anticoagulation with acenocoumarol following the same protocol: 3 mg for three consecutive days. Then, doses were individually adjusted to achieve a steady… CONTINUE READING

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