The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models

@inproceedings{Yen2013TheGH,
  title={The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models},
  author={Jennifer R. Yen and Richard M White and David C. Wedge and Peter Van Loo and Jeroen de Ridder and Amy Capper and Jennifer K. Richardson and David Jones and Keiran M Raine and Ian Robert Watson and Chang-jiun Wu and Jiqiu Cheng and I{\~n}igo Martincorena and Serena Nik-Zainal and Laura J. Mudie and Yves Moreau and John Marshall and Manasa Ramakrishna and P. Tarpey and Adam Shlien and Ian Whitmore and Steve Gamble and Calli Latimer and Erin Langdon and Charles K Kaufman and Mike Dovey and A. Malcolm R. Taylor and Alexander M. Menzies and Stuart R McLaren and Sarah J. O’Meara and Adam P. Butler and Jon W. Teague and James A Lister and Lynda Chin and Peter J. Campbell and David J. Adams and Leonard I. Zon and E Elizabeth Patton and Derek L. Stemple and Phillip Andrew Futreal},
  booktitle={Genome Biology},
  year={2013}
}
BackgroundMelanoma is the most deadly form of skin cancer. Expression of oncogenic BRAF or NRAS, which are frequently mutated in human melanomas, promote the formation of nevi but are not sufficient for tumorigenesis. Even with germline mutated p53, these engineered melanomas present with variable onset and pathology, implicating additional somatic mutations in a multi-hit tumorigenic process.ResultsTo decipher the genetics of these melanomas, we sequence the protein coding exons of 53 primary… CONTINUE READING
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