The genetic evolution of the envelope gene of simian immunodeficiency virus in cynomolgus macaques infected with a complex virus pool.

@article{Almond1992TheGE,
  title={The genetic evolution of the envelope gene of simian immunodeficiency virus in cynomolgus macaques infected with a complex virus pool.},
  author={Neil M. Almond and Adrian Jenkins and Alan B Heath and L F Taffs and P A Kitchin},
  journal={Virology},
  year={1992},
  volume={191 2},
  pages={996-1002}
}
Two cynomolgus macaques were infected with a complex, but characterized, challenge stock of simian immunodeficiency virus (SIVmac251 32H). The polymerase chain reaction was applied in a temporal sequence analysis to determine the sequences of the gp120 region of the SIV env gene, which were present in the blood of both macaques at 1, 6, and 15 months postinfection (p.i.). At 1 month p.i. selected sequences, which had been present in the original virus challenge stock, were reisolated. At later… CONTINUE READING